10.1210/jc.2011-2594 50
This does not mean sweat is dangerous
Many of the original preclinical studies used oral or intragastric administration
Several case reports have linked the use of these drugs, mainly exenatide, with the occurrence of acute kidney injury, primarily through hemodynamic derangement due to nausea, vomiting, and diarrhea [28]
481 However, the hydrophilic structure of deferoxamine results in poor absorption and rapid metabolism which forces frequent parenteral administration in patients (over 8 to 12 h per day), thus imposing a significant treatment burden
Semaglutide, a GLP-1 receptor agonist, has proved effective in glycemic control and weight loss, with it being the treatment of choice